Biophysical Model Including a Potentially Lethal Damage Repair Parameter in Fractionated Carbon Beam
조회 1,313
The
amount of potentially lethal damage repair (PLDR) is a significant factor in
the process of modeling the survival curves of cells irradiated with
fractionated carbon beams. Because the amount of PLDR generally depends on the
features of the cells and the linear energy transfer (LET), the amount of PLDR
of cells irradiated with fractionated carbon beams shows distinct differences
from that of cells irradiated with X-rays. This study considered a new
parameter dependent on the correlation between the PLDR trait (T) of the cells
over a time interval (Δ) at the fractionated carbon beam irradiation. The survival
curves of the cells irradiated with fractionated carbon beams n times were
predicted using the ζ and the Ψ values from the delay assay. This study aims to
overcome the barriers of traditional methods by developing a new survival curve
model with new parameters based on an analysis of the PLDR traits of cells over
time interval in fractionated carbon beam irradiation and to suggest a model
that produces results significantly closer to the experimental data.
Eunae Choi and Myonggeun Yoon∗
Department of Bio-convergence Engineering, Korea University, Seoul 02841, Korea
Masao Suzuki and Naruhiro Matsufuji
National Institutes for Quantum and Radiological Science and Technology, Chiba 263-8555, Japan
Wonguyn Jung
Korea Institute of Radiological and Medical Science, Seoul 01812, KoreaJournal
of the Korean Physical Society, Vol. 77, No. 2, July 2020, pp. 161∼167
