Potential prognostic factor in alternating electric fields therapy based on absorbed energy in tissue
조회 1,661
The present study aimed
to determine a method for estimating a potential prognostic factor in
alternating electric fields for the treatment of solid tumors based on cell
survival curves that evaluate cell proliferation capability. In AGS, B16F10,
U373, and HPAF-II cancer cell lines, the proportional relationships of the
electric field magnitude and the duration of application with the proliferation
of cancer cell lines was identified by in
vitro alternating current electric field experiments performed
under various conditions. A prognostic factor applicable to alternating
electric field therapy was developed by identifying proportional relationships
of the electric field magnitude and the duration of application with the
proliferation of the four cancer cell lines. Through the experimental results,
the absorbed energy in tissue has been suggested as a potential prognostic
factor in alternating electric field therapy. The absorbed energy in tissue can
be used as a reference to quantify the inhibition of cell proliferation related
to control, enabling systematic assessment of alternating electric field
therapy which, to date, has not been possible.
Geon Oh, Yongha Gi, Heehun Sung, Jaehyun Seo, Hyunwoo Kim
Department of Bioengineering, Korea University, Seoul 02841,Republic of Korea
Yunhui Jo
Institute of Global Health Technology(IGHT), Korea University, Seoul 02841, Republic of Korea
Jaemin Lee
Department of Internal Medicine, Anam Hospital, Korea University College of Medicine, Seoul 02841, Republic of Korea
Myonggeun Yoon
Department of Bioengineering, Korea University, Seoul 02841,Republic of Korea
FieldCure Ltd.,Seoul 02852, Republic of Korea
AIPAdvances12,095311(2022)
